How are chemical reactions which are discovered and researched in a laboratory setting translated into industrial-scale manufacturing processes?The 33rd SCI Process Development Symposium will explore this highly interdisciplinary field by bringing together a broad range of experts from various backgrounds.
An important area to address when developing new and more sustainable methodolgies for API manufacturing are non-technical barriers to the uptake of the emerging technology.A number of CHEM 21 members have collaborated with a range of other multi-national pharmaceutical companies and biotechnology suppliers to produce a white paper to support the uptake of biocatalysis in the manufacture of API’s. The paper details some case studies on medicines both in development and approved for patients, and provides some practical guidance around quality issues to promote the uptake of biocatalysis .
The 2016 Organic Process Research and Development paper has just been just accepted and can be viewed at:http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00369
On 4th and 5th November, WP 5 members contributed to a successful workshop and symposium on sustainable chemistry in industry organised by Durham Chemistry post graduate researchers. The event was very well attended by Durham scientists alongside researchers from York, Newcastle and Huddersfield Universities and some industry-based attendees from local chemistry using companies like Thomas Swan, High Force Research and Johnson Matthey. The event was a mixture of interactive workshop activities and presentations with the underlying theme of sustainable chemistry.Joining WP5 members in delivering the event were speakers from AstraZeneca, Syngenta, and Johnston Matthey.
Sustainability in Industrial Chemistry final programme (1)
A number of CHEM 21 members have contributed to an article on a more sustainable pharmaceutical industry through collaboration – The Medicine Maker Feb 2015 edition
An excellent event to learn more about some technologies that allow very efficient and green chemical transformations.
The 32nd Process Development Symposium will take place from Wednesday 25 March – Friday 27 March 2015.These meetings bring together experts from across the entire spectrum of the discipline to present state of the art process development.
The young chemists panel of the SCI have organised a one day meeting Practical Green Chemistry: Truths, Myths and Medicines in London on 11th November. In order to attract students and young researchers, the event is free! This one day conference features many CHEM 21 speakers. Please see link for program and registration details
On February 3rd and 4th, representatives of CHEM 21 Work Packages 3 & 5 were invited to attend the 18 month review meeting of BIOINTENSE ( http://www.biointense.nu/ ) at the Technical University of Denmark (DTU).BIOINTENSE is an FP7 single stage knowledge based bio economy (KBBE) collaborative project which started on the 1st of August 2012.The main objectives in BIOINTENSE are to increase biocatalyst productivity and process intensity.The consortium is led by Professor John Woodley from the PROCESS group at the Department of Chemical and Biochemical Engineering at the DTU. Of key interest to CHEM 21 are the BIOINTENSE work packages looking at the process intensification of biocatalytic reactions and novel sensor technology being developed to measure pH and Oxygen content at multiple points in micro-channel flow reactors, which of course could be applicable to activities across WP 2 and WP 3. From CHEM 21, BIOINTENSE researchers were keen to learn about our approach to the use of solvent selection guides and solvent selection, greener solvents , especially for use in combination with enzyme catalysed processes.
It is anticipated that CHEM 21 and BIOINTENSE will keep in close contact moving forward.
CHEM 21 representatives from work packages 1 and 5 attended the International Workshop in Delhi Dec 2-3 2013. The gathering was a busy and vibrant meeting, with ~200 delegates from academia and industry, including leaders representing green chemistry centres from the UK, Canada, USA, Brazil, Korea, Mexico and of course a very strong turn out from the local host country, India. The workshop was centred around a diverse range of presentations and posters on bio renewables and biofuels, novel catalysts, medicinal chemistry, greener processing and renewable energy. The meeting included presentations from Indian state ministers.
There was a great deal of interest in the CHEM 21 presentation and posters, with CHEM 21 PhD student, Giulia, from York University, winning a poster prize for her research on bio-based solvents for enzyme catalysed reactions. A key take home message from the workshop sessions was that there a lot of enthusiasm for closer links and cooperation between the existing green chemistry centres and that they should combine forces to share knowledge and best practice to maximise impact and to help embryonic and emerging green chemistry centres throughout the world. The key workshop outputs were that existing leaders of green chemistry centres were tasked with setting up a joint website as a vehicle to start the closer collaboration and knowledge sharing, and challenged to investigate mechanisms and funding streams to help foster closer collaboration and build on the momentum established at the Delhi workshop.
Workpackage 1 and 5 Representatives from CHEM 21 will attend the International Workshop On Green Initiatives in Energy, Environment & Health, Delhi, 2-3 December.The meeting will look at pathways for designing, adapting and incorporating new green strategies in industries as well as in academia.A key area will be best practice in sharing and international collaboration in green chemistry.