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The elusive structure of Pd2(dba)3 – Examination by isotopic labelling, NMR spectroscopy and X-ray diffraction analysis: synthesis and characterization of Pd2(dba-Z)3 complexes http://www.ncbi.nlm.nih.gov/pubmed/23701049
Synthesis of C8-N9 Annulated Purines via Iron Catalyzed C-H Amination http://www.ncbi.nlm.nih.gov/pubmed/23733404
Palladium-Catalysed Carbonylative a-Arylation of Acetone and Acetophenones to 1,3-Diketones http://onlinelibrary.wiley.com/doi/10.1002/chem.201302590/abstract
A Novel Double Carbonylation Reaction of Aryl Halides: Selective Synthesis of 5-Arylfuranones http://www.ncbi.nlm.nih.gov/pubmed/24022987
Synthetic core promoter design for Pichia pastoris http://www.ncbi.nlm.nih.gov/pubmed/24187969
Multicomponent reactions as sustainable synthetic tools http://pubs.rsc.org/en/content/articlelanding/2014/gc/c4gc00013g#!divAbstract
Selective Palladium-Catalyzed Direct C-H Arylation of Unsubstituted N-Protected Pyrazoles http://onlinelibrary.wiley.com/doi/10.1002/adsc.201301139/abstract
Biocatalysis in bio-derived solvents: an improved approach for medium optimisation http://pubs.rsc.org/en/content/articlelanding/2014/gc/c3gc42526f#!divAbstract
Biocatalysis as a Strategic Green Technology for the Chemical Industry http://onlinelibrary.wiley.com/doi/10.1002/cctc.201402065/abstract
Enzyme toolbox: novel enantiocomplementary imine reductases. http://www.ncbi.nlm.nih.gov/pubmed/25163890
A Direct C-H/Ar-H Coupling Approach to Oxindoles, Thio-oxindoles, 3,4-Dihydro-1 H-quinolin-2-ones and ,2,3,4-Tetrahydroquinolines http://onlinelibrary.wiley.com/doi/10.1002/chem.201403917/abstract
A Survey of Solvent Selection Guides http://pubs.rsc.org/en/content/articlelanding/2014/gc/c4gc01149j#!divAbstract
Catalytic bio–chemo and bio–bio tandem oxidation reactions for amide and carboxylic acid synthesis http://pubs.rsc.org/en/Content/ArticleLanding/2014/GC/c4gc01321b#!divAbstract
Survey of Solvent Usage in Papers Published in Organic Process Research and Development 1997-2012. http://pubs.acs.org/doi/abs/10.1021/op500276u
Synthesis of Secondary Amides from N-Substituted Amidines by Tandem Oxidative Rearrangement and Isocyanate Elimination http://onlinelibrary.wiley.com/doi/10.1002/adsc.201400648/abstract
Organofluorine chemistry: applications, sources and sustainability http://pubs.rsc.org/en/content/articlelanding/2015/gc/c4gc02166e#!divAbstract
Palladium-Catalyzed Carbonylative α-Arylation to β-Ketonitriles http://onlinelibrary.wiley.com/doi/10.1002/chem.201402893/abstract
Compact multi-enzyme pathways in P. Pastoris . http://www.ncbi.nlm.nih.gov/pubmed/25502218
Towards a holistic approach to metrics for the 21st Century pharmaceutical industry http://pubs.rsc.org/en/content/articlelanding/2015/gc/c5gc00340g#!divAbstract
Ruthenium-Catalyzed Hydroaroylation of Styrenes in Water through Directed C-H Bond Activation http://onlinelibrary.wiley.com/doi/10.1002/cctc.201402031/abstract
An (R)-Imine Reductase [(R)-IRED] Biocatalyst for the Asymmetric Reduction of Cyclic Imines.http://onlinelibrary.wiley.com/doi/10.1002/cctc.201402797/abstrac
Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/C5GC00707K#!divAbstract
Enzymatic Synthesis of Optically Active Lactones via Asymmetric Bioreduction using Ene-Reductases from the Old Yellow Enzyme Family http://onlinelibrary.wiley.com/doi/10.1002/adsc.201500094/abstract
Palladium-Catalyzed Direct C–H Arylation of Dicyanobenzenes http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201500288/abstract
Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/C5GC00402K#!divAbstract
A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd0 nanoparticles? http://pubs.rsc.org/en/content/articlehtml/2014/cc/c3cc48481e
Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis http://onlinelibrary.wiley.com/doi/10.1002/cctc.201500218/abstract;jsessionid=FC00ECCEA62312E4FE99A781B2332674.f02t04 .
Redox-Active NOx Ligands in Palladium-Mediated Processes http://onlinelibrary.wiley.com/doi/10.1002/anie.201411487/abstract
a-C -Glycosides via syn Opening of 1,2-Anhydro Sugars with Organozinc Compounds in Toluene/n ‑Bu2 O http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b01472?journalCode=joceah
Selective hydrogenation of halogenated nitroaromatics to haloanilines in batch and flow http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00170
Expanding the Threonine Aldolase Toolbox for the Asymmetric Synthesis of Tertiary a-Amino Acids. http://www.ncbi.nlm.nih.gov/pubmed/26189018
2-Fluoromalonate esters: fluoroaliphatic building blocks for the life sciences. http://pubs.acs.org/doi/abs/10.1021/op500141c
Fluorotetrahydroquinolines from diethyl 2-fluoromalonate ester. http://www.ncbi.nlm.nih.gov/pubmed/25198753
Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-10-119
Sustainable Three-Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines. http://onlinelibrary.wiley.com/doi/10.1002/anie.201406717/abstract
A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris http://femsyr.oxfordjournals.org/content/15/7/fov082
Combinatorial pathway assembly in yeast http://www.aimspress.com/article/10.3934/bioeng.2015.4.423
Active Site Diversification of P450cam with Indole Generates Catalysts for Stereoselective Benzylic Oxidation http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-11-186
Engineering Pichia pastoris for improved NADH regeneration: A novel platform strain for whole-cell catalysis http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-11-190
Sustainable synthesis of enantiopure fluorolactam derivatives by a selective direct fluorination – amidase strategy http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/c5gc02209f#!divAbstrac
Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-11-26
A Convergent, Umpoled Synthesis of 2-(1-Amidoalkyl)pyridines http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-12-1
Whole-cell biocatalysts for stereoselective C-H amination reactions. http://www.ncbi.nlm.nih.gov/pubmed/2668985
CHAPTER Protein building blocks and the expansion of the genetic code CHAPTER Key methods for synthetic biology: Genome engineering and DNA assembly. In “Synthetic Biology” ISBN 978-3-319-22708-5 Editors: Glieder, A., Kubicek, C.P., Mattanovich, D., Wiltschi, B., Sauer, M. (Eds.) http://www.springer.com/us/book/9783319227078
Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form http://pubs.acs.org/author/Wells%2C+Andrew+S
Multivariate optimization of CRISPR/Cas9 expression enables precision genome engineering in the methylotrophic yeast Pichia pastoris http://www.ncbi.nlm.nih.gov/pubmed/27015975
A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris http://pubs.acs.org/doi/abs/10.1021/acssynbio.5b00199
Catalytic C–H bond functionalisation chemistry: the case for quasi-heterogeneous catalysis http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC06980G#!divAbstract
CHEM21 Selection Guide of Classical -and Less Classical- Solvents http://pubs.rsc.org/en/content/articlelanding/gc/2016/c5gc01008j#!divAbstract
Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions. http://www.ncbi.nlm.nih.gov/pubmed/27112103
Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanidehttp://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01481
Combinatorial optimization of CRISPR/Cas9 expression enables precision genome engineering in the methylotrophic yeast Pichia pastoris. http://www.ncbi.nlm.nih.gov/pubmed/27015975
On the potential of homogeneous Pd catalyst separation by ceramic membranes. Application to down-stream and continuous Flow processes http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00418
Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01023
An enantio- and diastereoselective chemoenzymatic synthesis of a-fluoro b-hydroxy carboxylic esters http://onlinelibrary.wiley.com/doi/10.1002/anie.201602852/full
Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01481?journalCode=orlef7
Catalyst Efficacy of Homogeneous and Heterogeneous Palladium Catalysts in the Direct Arylation of Common Heterocycles http://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1561436
Remote Functionalization: Palladium-Catalyzed C5(sp3)-H Arylation of 1-Boc-3-aminopiperidine Through the Use of a Bidentate Directing Group. http://pubs.acs.org/doi/abs/10.1021/acscatal.6b00841
A Journey Through Metal-Catalyzed C-H Functionalization of Heterocycles: Insights and Trends. http://www.sciencedirect.com/science/article/pii/S0065272516300289
Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones http://onlinelibrary.wiley.com/doi/10.1002/cctc.201500764/ful
Promoting the uptake of green and sustainable methodologies in pharmaceutical synthesis: CHEM21 education and training initiatives http://www.sciencedirect.com/science/article/pii/S2352554116300213
Encapsulated cobalt oxide on carbon nanotube support as catalyst for selective continuous hydrogenation of the showcase substrate 1-iodo-4-nitrobenzene http://onlinelibrary.wiley.com/wol1/doi/10.1002/adsc.201600461/abstract
An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01928E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29&utm_content=Google+UK#!divAbstract
Metal-Free One-Pot α-Carboxylation of Primary Alcohols http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C6OB01813K#!divAbstract
Precious-Metal-Free Heteroarylation of Azlactones: Direct Synthesis of a-Pyridyl,a-Substituted Amino Acid Derivatives http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b02731#cor
Refined Pichia pastoris reference genome sequence .://www.sciencedirect.com/science/article/pii/S0168165616302036
Anthranoyl-CoA Monooxygenase/Reductase from Azoarcus evansii Possesses Both FMN and FAD in Two Distinct and Independent Active Sites. http://www.ncbi.nlm.nih.gov/pubmed/25843773
Biocatalytic Access to Nonracemic g-Oxo Esters via Stereoselective Reduction Using Ene-Reductases. http://pubs.rsc.org/en/content/articlelanding/2017/gc/c6gc02493a#!divAbstract
Sequential Enzymatic Conversion of a-Angelica Lactone to g-Valerolactone via Hydride-Independent C=C Bond Isomerization http://onlinelibrary.wiley.com/doi/10.1002/cssc.201601363/full
Modular Approach to Tricyclic Heterocycles via Copper and Palladium Mediated C-H activation http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201700356/full
One-step continuous flow synthesis of WHO Essential Medicine Flucytosine using fluorine http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00420
Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201601432/full
Continuous Selective Hydrogenation of Refametinib Iodo-nitroaniline Key Intermediate DIM-NA over Raney Cobalt Catalyst at kg/day Scale with Online UV–Visible Conversion Control http://pubs.acs.org/doi/abs/10.1021/acs.oprd.7b00039
An Evaluation of the Green Credentials of a Multicomponent Reaction for the Synthesis of Isothioureas Through the Use of the Holistic CHEM21 Green Metrics Toolkit http://pubs.rsc.org/en/content/articlelanding/2017/gc/c6gc01928e#!divAbstract
Metal-Free One-Pot α-Carboxylation of Primary Alcohols http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C6OB01813K#!divAbstract
Precious-Metal-Free Heteroarylation of Azlactones: Direct Synthesis of α-Pyridyl, α-Substituted Amino Acid Derivatives http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b02731
Concise Xanthine Synthesis through a Double-Amidination Reaction of a 6-Chlorouracil with Amidines using Base-Metal Catalysis http://onlinelibrary.wiley.com/doi/10.1002/cssc.201601483/abstract
Carbon–Nitrogen Bond Formation Through Cross-Dehydrogenative Coupling Reactions http://www.sciencedirect.com/science/article/pii/S0065305517300059
Continuous Platinum-mediated Hydrogenation of Refametinib Iodo-nitroaniline. Key Intermediate DIM-NA: The Combined Challenges of Selectivity and Catalyst Deactivation http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201700625/abstract
Amine Activation: N-Arylamino Acid Amide Synthesis from Isothioureas and Amino Acids http://onlinelibrary.wiley.com/doi/10.1002/adsc.201700134/abstract
http://pubs.acs.org/doi/abs/10.1021/acscentsci.7b00275
Combining Isocyanides with Carbon Dioxide in Palladium-Catalyzed Heterocycle Synthesis: N3‑Substituted Quinazoline-2,4(1H,3H)‑diones via a Three-Component Reaction http://pubs.acs.org/doi/abs/10.1021/acscatal.7b01503
Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines. http://pubs.acs.org/doi/abs/10.1021/acscatal.7b00513
Highly Productive Continuous Flow Synthesis of Di- and Tripeptides in Water http://pubs.acs.org/doi/abs/10.1021/acs.oprd.7b00214
Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines http://www.ncbi.nlm.nih.gov/pubmed/28764963
Ferrier Rearrangement of 1,2-Dihydropyrans with organozinc species in Toluene/n-Dibutyl Ether http://www.researchgate.net/publication/318535446_Ferrier_Rearrangement_of_12-Dihydropyrans_with_Organozinc_Species_in_Toluenen-Dibutyl_Ether
Polymer encapsulated Co metal based catalysts (Co EnCatTM ) for selective continuous hydrogenation of 1-iodo-4-nitrobenzene http://onlinelibrary.wiley.com/doi/10.1002/cctc.201700391/full
Incorporation of non-canonical amino acids into proteins in yeast. http://www.ncbi.nlm.nih.gov/pubmed/26868890
Novel biological approaches in synthesis chemistry http://www.tugraz.at/en/tu-graz/services/news-stories/planet-research/singleview/article/neue-biologische-ansaetze-fuer-die-synthesechemie/
Efficient biocatalytic reductive aminations by extending the imine reductase toolbox http://onlinelibrary.wiley.com/doi/10.1002/cctc.201701379/abstract
Considerations for selection of organic solvents applied to biphasic systems for in-situ product recovery and downstream processing in bioprocesses (to be published)
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