Publications

2013

  1. The elusive structure of Pd2(dba)3 – Examination by isotopic labelling, NMR spectroscopy and X-ray diffraction analysis: synthesis and characterization of Pd2(dba-Z)3 complexes http://www.ncbi.nlm.nih.gov/pubmed/23701049
  2. Synthesis of C8-N9 Annulated Purines via Iron Catalyzed C-H Amination http://www.ncbi.nlm.nih.gov/pubmed/23733404
  3. Palladium-Catalysed Carbonylative a-Arylation of Acetone and Acetophenones to 1,3-Diketones http://onlinelibrary.wiley.com/doi/10.1002/chem.201302590/abstract
  4. A Novel Double Carbonylation Reaction of Aryl Halides: Selective Synthesis of 5-Arylfuranones  http://www.ncbi.nlm.nih.gov/pubmed/24022987
  5. Synthetic core promoter design for Pichia pastoris  http://www.ncbi.nlm.nih.gov/pubmed/24187969
  6. Multicomponent reactions as sustainable synthetic tools http://pubs.rsc.org/en/content/articlelanding/2014/gc/c4gc00013g#!divAbstract
  7. Selective Palladium-Catalyzed Direct C-H Arylation of Unsubstituted N-Protected Pyrazoles http://onlinelibrary.wiley.com/doi/10.1002/adsc.201301139/abstract
  8. Biocatalysis in bio-derived solvents: an improved approach for medium optimisation http://pubs.rsc.org/en/content/articlelanding/2014/gc/c3gc42526f#!divAbstract
  9. Biocatalysis as a Strategic Green Technology for the Chemical Industry http://onlinelibrary.wiley.com/doi/10.1002/cctc.201402065/abstract
  10. Enzyme toolbox: novel enantiocomplementary imine reductases. http://www.ncbi.nlm.nih.gov/pubmed/25163890
  11. A Direct C-H/Ar-H Coupling Approach to Oxindoles, Thio-oxindoles, 3,4-Dihydro-1 H-quinolin-2-ones and ,2,3,4-Tetrahydroquinolines http://onlinelibrary.wiley.com/doi/10.1002/chem.201403917/abstract
  12. A Survey of Solvent Selection Guides  http://pubs.rsc.org/en/content/articlelanding/2014/gc/c4gc01149j#!divAbstract
  13. Catalytic bio–chemo and bio–bio tandem oxidation reactions for amide and carboxylic acid synthesis http://pubs.rsc.org/en/Content/ArticleLanding/2014/GC/c4gc01321b#!divAbstract
  14. Survey of Solvent Usage in Papers Published in Organic Process Research and Development 1997-2012. http://pubs.acs.org/doi/abs/10.1021/op500276u
  15. Synthesis of Secondary Amides from N-Substituted Amidines by Tandem Oxidative Rearrangement and Isocyanate Elimination http://onlinelibrary.wiley.com/doi/10.1002/adsc.201400648/abstract
  16. Organofluorine chemistry: applications, sources and sustainability http://pubs.rsc.org/en/content/articlelanding/2015/gc/c4gc02166e#!divAbstract
  17. Palladium-Catalyzed Carbonylative α-Arylation to β-Ketonitriles http://onlinelibrary.wiley.com/doi/10.1002/chem.201402893/abstract
  18. Compact multi-enzyme pathways in P. Pastoris.  http://www.ncbi.nlm.nih.gov/pubmed/25502218
  19. Towards a holistic approach to metrics for the 21st Century pharmaceutical industry http://pubs.rsc.org/en/content/articlelanding/2015/gc/c5gc00340g#!divAbstract
  20. Ruthenium-Catalyzed Hydroaroylation of Styrenes in Water through Directed C-H Bond Activation http://onlinelibrary.wiley.com/doi/10.1002/cctc.201402031/abstract
  21. An (R)-Imine Reductase [(R)-IRED] Biocatalyst for the Asymmetric Reduction of Cyclic Imines.http://onlinelibrary.wiley.com/doi/10.1002/cctc.201402797/abstrac
  22. Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/C5GC00707K#!divAbstract
  23. Enzymatic Synthesis of Optically Active Lactones via Asymmetric Bioreduction using Ene-Reductases from the Old Yellow Enzyme Family http://onlinelibrary.wiley.com/doi/10.1002/adsc.201500094/abstract
  24. Palladium-Catalyzed Direct C–H Arylation of Dicyanobenzenes http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201500288/abstract
  25. Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/C5GC00402K#!divAbstract
  26. A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd0 nanoparticles? http://pubs.rsc.org/en/content/articlehtml/2014/cc/c3cc48481e
  27. Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis http://onlinelibrary.wiley.com/doi/10.1002/cctc.201500218/abstract;jsessionid=FC00ECCEA62312E4FE99A781B2332674.f02t04 .
  28. Redox-Active NOx Ligands in Palladium-Mediated Processes http://onlinelibrary.wiley.com/doi/10.1002/anie.201411487/abstract
  29. a-C-Glycosides via syn Opening of 1,2-Anhydro Sugars with Organozinc Compounds in Toluene/n‑Bu2O http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b01472?journalCode=joceah
  30. Selective hydrogenation of halogenated nitroaromatics to haloanilines in batch and flow                                        http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00170
  31. Expanding the Threonine Aldolase Toolbox for the Asymmetric Synthesis of Tertiary a-Amino Acids. http://www.ncbi.nlm.nih.gov/pubmed/26189018
  32. 2-Fluoromalonate esters: fluoroaliphatic building blocks for the life sciences. http://pubs.acs.org/doi/abs/10.1021/op500141c
  33. Fluorotetrahydroquinolines from diethyl 2-fluoromalonate ester. http://www.ncbi.nlm.nih.gov/pubmed/25198753
  34. Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-10-119
  35. Sustainable Three-Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines. http://onlinelibrary.wiley.com/doi/10.1002/anie.201406717/abstract
  36. A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris http://femsyr.oxfordjournals.org/content/15/7/fov082
  37. Combinatorial pathway assembly in yeast http://www.aimspress.com/article/10.3934/bioeng.2015.4.423
  38. Active Site Diversification of P450cam with Indole Generates Catalysts for Stereoselective Benzylic Oxidation             http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-11-186
  39. Engineering Pichia pastoris for improved NADH regeneration: A novel platform strain for whole-cell catalysis                 http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-11-190
  40. Sustainable synthesis of enantiopure fluorolactam derivatives by a selective direct fluorination – amidase strategy http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/c5gc02209f#!divAbstrac
  41. Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-11-26
  42. A Convergent, Umpoled Synthesis of 2-(1-Amidoalkyl)pyridines http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-12-1
  43. Whole-cell biocatalysts for stereoselective C-H amination reactions. http://www.ncbi.nlm.nih.gov/pubmed/2668985
  44. CHAPTER Protein building blocks and the expansion of the genetic code CHAPTER Key methods for synthetic biology: Genome engineering and DNA assembly. In “Synthetic Biology” ISBN 978-3-319-22708-5 Editors: Glieder, A., Kubicek, C.P., Mattanovich, D., Wiltschi, B., Sauer, M. (Eds.)  http://www.springer.com/us/book/9783319227078
  45. Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form                         http://pubs.acs.org/author/Wells%2C+Andrew+S
  46. Multivariate optimization of CRISPR/Cas9 expression enables precision genome engineering in the methylotrophic yeast Pichia pastoris http://www.ncbi.nlm.nih.gov/pubmed/27015975
  47. A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris http://pubs.acs.org/doi/abs/10.1021/acssynbio.5b00199
  48. Catalytic C–H bond functionalisation chemistry: the case for quasi-heterogeneous catalysis      http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC06980G#!divAbstract
  49.  CHEM21 Selection Guide of Classical -and Less Classical- Solvents   http://pubs.rsc.org/en/content/articlelanding/gc/2016/c5gc01008j#!divAbstract
  50. Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions. http://www.ncbi.nlm.nih.gov/pubmed/27112103
  51. Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanidehttp://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01481
  52. Combinatorial optimization of CRISPR/Cas9 expression enables precision genome engineering in the methylotrophic yeast Pichia pastoris. http://www.ncbi.nlm.nih.gov/pubmed/27015975
  53. On the potential of homogeneous Pd catalyst separation by ceramic membranes. Application to down-stream and continuous Flow processes http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00418
  54. Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates                   http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01023
  55. An enantio- and diastereoselective chemoenzymatic synthesis of a-fluoro b-hydroxy carboxylic esters      http://onlinelibrary.wiley.com/doi/10.1002/anie.201602852/full
  56. Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide  http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01481?journalCode=orlef7
  57. Catalyst Efficacy of Homogeneous and Heterogeneous Palladium Catalysts in the Direct Arylation of Common Heterocycles                                     https://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1561436
  58. Remote Functionalization: Palladium-Catalyzed C5(sp3)-H Arylation of 1-Boc-3-aminopiperidine Through the Use of a Bidentate Directing Group.         http://pubs.acs.org/doi/abs/10.1021/acscatal.6b00841
  59. A Journey Through Metal-Catalyzed C-H Functionalization of Heterocycles: Insights and Trends. http://www.sciencedirect.com/science/article/pii/S0065272516300289
  60. Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones                     http://onlinelibrary.wiley.com/doi/10.1002/cctc.201500764/ful
  61. Promoting the uptake of green and sustainable methodologies in pharmaceutical synthesis: CHEM21 education and training initiatives http://www.sciencedirect.com/science/article/pii/S2352554116300213
  62. Encapsulated cobalt oxide on carbon nanotube support as catalyst for selective continuous hydrogenation of the showcase substrate 1-iodo-4-nitrobenzene http://onlinelibrary.wiley.com/wol1/doi/10.1002/adsc.201600461/abstract
  63. An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01928E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29&utm_content=Google+UK#!divAbstract
  64. Metal-Free One-Pot α-Carboxylation of Primary Alcohols http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C6OB01813K#!divAbstract
  65. Precious-Metal-Free Heteroarylation of Azlactones: Direct Synthesis of a-Pyridyl,a-Substituted Amino Acid Derivatives http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b02731#cor
  66. Refined Pichia pastoris reference genome sequence .://www.sciencedirect.com/science/article/pii/S0168165616302036
  67. Anthranoyl-CoA Monooxygenase/Reductase from Azoarcus evansii Possesses Both FMN and FAD in Two Distinct and Independent Active Sites. https://www.ncbi.nlm.nih.gov/pubmed/25843773
  68. Biocatalytic Access to Nonracemic g-Oxo Esters via Stereoselective Reduction Using Ene-Reductases. http://pubs.rsc.org/en/content/articlelanding/2017/gc/c6gc02493a#!divAbstract
  69. Sequential Enzymatic Conversion of a-Angelica Lactone to g-Valerolactone via Hydride-Independent C=C Bond Isomerization http://onlinelibrary.wiley.com/doi/10.1002/cssc.201601363/full